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Publications

Gurumurthy RK, Kumar N, Chumduri C. Culturing and Differentiation of Patient-derived Ectocervical Epithelial Stem Cells using Air-Liquid Interphase and Matrigel Scaffold. 
Epithelial Cell Culture, Second Edition - Methods and Protocols, Springer Nature 2023, In press.
 
 
Dong J, Holthaus D, Peters C, Koster S, Ehsani M, Quevedo-Olmos A, Berger H, Zarobkiewicz M, Mangler M, Gurumurthy RK, Hedemann, Chumduri C+, Kabelitz D+, Meyer T.F.+. γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids. 
BioRxiv 2023 July 26. https://doi.org/10.1101/2023.07.25.550464. +Lead Corresponding authors.
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Koster S, Gurumurthy RK, Kumar N, Prakash PG, Dhanraj J, Bayer S, Berger H, Kurian SM, Drabkina M, Mollenkopf HJ, Goosmann C, Brinkmann V, Nagel Z, Mangler M, Meyer TF, Chumduri C. Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming.
Nature Communications. 2022 Feb 24;13(1):1030. https://doi.org/10.1038/s41467-022-28569-1
 
 
 
Gurumurthy RK, Kumar N, Chumduri C. Spatial analysis of organ-wide RNA, protein expression, and lineage tracing in the female mouse reproductive tract.
STAR Protocols, 2021 Nov 17;2(4), https://doi.org/10.1016/j.xpro.2021.100969
 
 
Gurumurthy RK, Kumar N, Chumduri C. Optimized protocol for isolation of high-quality single cells from the female mouse reproductive tract tissues for single-cell RNA sequencing.
STAR Protocols, 2021 Nov 17;2(4), https://doi.org/10.1016/j.xpro.2021.100970
 
 
Kumar N, Gurumurthy RK,  Prakash PG, Kurian SM, Wentland C, Brinkmann V, Mollenkopf HJ, Krammer T, Toussaint C, Saliba AE, Biebl M, Juergensen C, Wiedenmann B, Meyer TF, Chumduri C. Spatial organisation and homeostasis of epithelial lineages at the 2 gastroesophageal junction is regulated by the divergent Wnt mucosal 3 microenvironment.
bioRxiv, 2021, https://doi.org/10.1101/2021.08.05.455222
Koster S, Gurumurthy RK, Berger H, Drabkina M, Mollenkopf H-J, Goosmann C, Brinkmann V, Nagel Z, Mangler M, Meyer TF, Chumduri C. Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids.
bioRxiv, 2021, https://doi.org/10.1101/2021.04.15.439996 
Chumduri  C+. and Turco MY+., Organoids of the Female Reproductive Tract.
Jounal of Molecular Medicine 2021, DOI: 10.1007/s00109-020-02028-0.  +Corresponding authors
 
 
 
Chumduri C+, Gurumurthy RK, Berger H, Dietrich O, Kumar N, Koster S, Brinkmann V, Hoffmann K, Drabkina M, Arampatzi P, Son D, Klemm U, Mollenkopf HJ, Herbst H, Mangler M, Vogel J, Saliba AE, Meyer TF+ (2020). Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.
Nature Cell Biology, 2021, DOI: 10.1038/s41556-020-00619-0. +Corresponding authors
Chumduri C+. and Turco MY+., 3.7 Organoide des weiblichen Reproduktionstraktes, in Organoide: Ihre Bedeutung für Forschung, Medizin und Gesellschaft,
Nomos Verlagsgesellschaft mbH & Co. KG: Baden-Baden. 2020, p. 131-137. +Corresponding authors
Zadora PK*, Chumduri C*, Imami K, Berger H, Mi Y, Selbach M, Meyer TF, Gurumurthy RK. Integrated Phosphoproteome and Transcriptome Analysis Reveals Chlamydia-Induced Epithelial-to-Mesenchymal Transition in Host Cells. 
Cell Rep. 2019 Jan 29;26(5):1286-1302.e8. * First authors.
Mi Y, Gurumurthy RK, Zadora PK, Meyer TF, Chumduri C. Chlamydia trachomatis promotes non-homologous end joining by modulating ATM signaling via protein phosphatase 2A.
mBio. 2018 Nov 6;9(6):e01465-18.
Rother M, Gonzalez E, Teixeira da Costa AR, Wask L, Gravenstein I, Pardo M, Pietzke M, Gurumurthy RK, Angermann J, Laudeley R, Glage S, Meyer M, Chumduri C, Kempa S, Dinkel K, Unger A, Klebl B, Klos A, Meyer TF. Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection.
Cell Host Microbe. 2018 May 9;23(5):661-671.e8.
Chumduri C, Gurumurthy RK, Berger H, Koster S, Brinkmann V, Klemm U, Mollenkopf HJ, Herbst H, Mangler M, Meyer TF. Transition of Wnt signaling microenvironment delineates the squamocolumnar junction and emergence of squamous metaplasia of the cervix.
bioRxiv, 2018, https://doi.org/10.1101/443770.
Müller A, Gillissen B, Richter A, Richter A, Chumduri C, Daniel PT, Scholz CW.  Pan-class I  PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53.
Cell Death Dis. 2018 Mar 7;9(3):384. 
 
Chumduri C, Gurumurthy RK, Zietlow R, Meyer TF. Subversion of host genome integrity by bacterial pathogens.
Nat Rev Mol Cell Biol. 2016 Oct;17(10):659-73.
 
Chumduri C, Gillissen B, Richter A, Richter A, Milojkovic A, Overkamp T, Müller A, Pott C, Daniel PT. Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma.
J Mol Med (Berl). 2015 May;93(5):559-72. 
 
Gurumurthy RK*, Chumduri C*, Karlas A*, Kimmig S, Gonzalez E, Machuy N, Rudel T, Meyer TF. Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.
Mol Microbiol. 2014 Oct;94(1):186-201. * First authors. 
 
Milojkovic A, Hemmati PG, Müer A, Overkamp T, Chumduri C, Jänicke RU, Gillissen B, Daniel PT. p14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop.
Int J Cancer. 2013 Dec 1;133(11):2551-62. 
 
Müller A, Zang C, Chumduri C, Dörken B, Daniel PT, Scholz CW. Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.
Int J Cancer. 2013 Oct 15;133(8):1813-24. 
 
Chumduri C, Gurumurthy RK, Zadora PK, Mi Y, Meyer TF. Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response.
Cell Host Microbe. 2013 Jun 12;13(6):746-58. 
 
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