Chumduri, C., Turco, M.Y. Organoids of the female reproductive tract. J Mol Med (2021).
This comprehensive review covers female reproductive tract biology and the state of the art of developments of various organoid models, their applications, and future perspectives.
Glad to share that our recently published article in Nature Cell Biology. Pioneering and comprehensive findings in this study provide critical insights into the cervix biology and the transition points between the healthy and early carcinogenesis events. In this work, we: 1. Developed novel organoid models of the stratified and columnar epithelium of the cervix. 2. Generated complete cellular atlas of the uterine cervix. 3. Demonstrated the molecular mechanism of squamous metaplasia emergence, a precancerous condition. 4. Showed that adenocarcinomas and squamous cell carcinomas arise from different stem cell lineages.
This chapter provides an authoritative summary of state of the art regarding the developments of the organoid systems of various parts of the female reproductive tract, their applications and future perspectives.